Salicylic acid is a remedy for antipyretic and anti-inflammatory analgesics. Analgesics is a remedy for pain relief by increasing the pain threshold value of the saradacic system without suppressing consciousness, whereas antipyretics is a drug that suppresses body temperature in fever. Since both effects are present in one drug, the term analgesic-antipyretic is used as a whole. While anti-inflammatory is addressing inflammation / inflammation (Djamhuri, 1995) the oldest natural remedy as an antipyretic and anti-inflammatory analgesic is developed from salicylic acid to salt (eg, aspirin, salicillamide, methyl salicylate and saligenin), used as an antipyretic analgesic only sodium salicylate, salicillamide and the most commonly used aspirin (Ganiswara 1995)s
Due to its highly irritating nature, its use is orally avoided. Various modifications have been made to the salicylic acid structure to minimize side effects and to increase the activity of these compounds in addition to producing compounds which may be used orally. Modification of the structure that has been done is on the carboxyl group, phenolic hydroxy groups, as well as on the benzene ring. The resultant modified hydroxy phenolic group is acetyl salicylic acid which is efficacious as analgesic-antipyretic, anti-inflammatory and antiplatelet. The modified carboxyl group modified compounds include methyl salicylate for topical application, while the modified sample of the benzene ring is diflusinal. (Rudyanto, 2005)
Salicylic acid can be obtained from the synthesis of Methyl Salicylate. Methyl salicylate or gandapura oil is a material that has various uses. As an ingredient of methyl salicylic acid is one of the non-steroidal anti-inflammatory drugs (NSAIDs) of the salicylate group. This material can be made in the form of dosage form linimentum or ointment that serves to relieve pain in the waist, stump, and rheumatism.
Created by Fazira Hally